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Is acyclovir an antiviral
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Drug Description, zovirax (acyclovir) Cream, 5, description, zovirax is the brand name for acyclovir, a synthetic nucleoside acyclovir ointment analogue active against herpes viruses. Zovirax Cream, 5 is a formulation for topical administration. The chemical name of acyclovir is it has the following structural formula: Acyclovir is a white, crystalline powder with the molecular formula C8H11N5O3 and a molecular weight of 225. The maximum solubility in water at 37C.5 mg/mL. The pKa's of acyclovir are.27 and.25. Each gram of zovirax Cream, 5 contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol, mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum. Adult Skin Problems Slideshow. Quiz: Is Ringworm Contagious? Gallery of Skin Problems and Image Collection. Indications Dosage, indications, zovirax Cream is a herpes simplex virus (HSV) nucleoside analogue, dNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older. Zovirax Cream should be applied five times per day for four days. Therapy should be initiated as acyclovir ointment early as possible following the onset of signs or symptoms of herpes labialis.e., during the prodrome or when lesions appear. For adolescents 12 years of age and older, the dosage is the same as in adults. HOW supplied, dosage Forms And Strengths, each gram of zovirax Cream, 5 contains 50 mg of acyclovir. Each gram of, zovirax Cream 5 contains 50 mg acyclovir in an aqueous cream base. Zovirax Cream is supplied as follows: 5 g tubes, nDC. Store at or below 25C (77F excursions permitted to 15 to 30C (59 to 86F) (see USP Controlled Room Temperature). Distributed by: Valeant Pharmaceuticals North America LLC, Bridgewater, NJ 08807. Manufactured by: GlaxoSmithKline, Mississauga, Ontario L5N 6L4 Canada For more information, call. Side Effects Drug Interactions, sIDE effects, clinical Trials Experience. Because acyclovir ointment clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug, and may not reflect the rates observed in practice. In five double-blind, placebo-controlled trials, 1,124 patients were treated with zovirax Cream and 1,161 with placebo (vehicle) cream. Local application site reactions were reported by 5 of patients receiving zovirax Cream and 4 of patients receiving placebo. The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, acyclovir ointment cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1 of patients receiving zovirax Cream and placebo. Three patients on zovirax Cream and one patient on placebo discontinued treatment due to an adverse event. An additional study, enrolling 22 healthy adults, was conducted to evaluate the dermal tolerance of zovirax Cream compared with vehicle using single occluded and semi-occluded patch testing methodology. Both zovirax Cream and placebo showed a high and cumulative irritation potential. Another study, enrolling 251 healthy adults, was conducted to evaluate the contact sensitization potential of zovirax Cream using repeat insult patch testing methodology. Of 202 evaluable subjects, possible cutaneous sensitization reactions were observed in the same 4 (2) subjects with both zovirax Cream and placebo, and these reactions to both zovirax Cream and placebo were confirmed in 3 subjects upon rechallenge. The sensitizing ingredient(s) has not been identified. The safety profile in patients 12 to 17 years of age was similar to that observed in adults. Postmarketing Experience In addition to adverse events reported from clinical trials, the following events have acyclovir ointment been identified during post-approval use of acyclovir cream. Because they are reported voluntarily from a population of unknown size, estimates acyclovir ointment of frequency cannot be made. These events have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to acyclovir cream. Skin: Contact dermatitis, eczema.